Video Source: Watch on YouTube
Retatrutide is an investigational triple agonist (GLP-1 + GIP + glucagon) and the newest “next-gen” metabolic drug everyone in the GLP-1 world is watching. In this video, Big Paul breaks down the new Phase 3 TRIUMPH-4 topline results in adults with obesity + knee osteoarthritis (without diabetes)—including the absolutely wild weight-loss numbers, the arthritis pain improvement, and the side effects people keep reporting.
What the TRIUMPH-4 topline data says (high level):
• Up to 28.7% average body-weight loss at 68 weeks on 12 mg (about 71.2 lbs on average).
• Knee pain improved by up to ~75.8%, plus better physical function.
• In a post-hoc analysis, ~12–14% of retatrutide-treated patients were completely free of knee pain at week 68 (vs ~4% placebo).
• Common GLP-1–style side effects showed up (nausea/diarrhea/constipation/vomiting), and dysesthesia (tingly/burning skin sensation) was reported in up to 20.9% at 12 mg (vs 0.7% placebo).
• Trial dosing started at 2 mg once weekly, increasing every 4 weeks step-wise until the 9 mg or 12 mg target.
• Lilly says additional Phase 3 readouts in obesity and type 2 diabetes are expected to complete in 2026.
We also talk about why the glucagon component may matter (energy expenditure, metabolic effects), why some people speculate these results could go beyond “just weight loss,” and what to watch for as more TRIUMPH program data drops.
👇 Drop your thoughts: Is Reta the future king of fat loss meds—or are the side effects the real story?
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#bodybuilding #retatrutide #glp1 #tirzepatide #semaglutide #weightloss #obesity #osteoarthritis #kneepain #clinicaltrials #pharma #metabolichealth #diabetes
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