{"id":937,"date":"2025-12-27T19:47:13","date_gmt":"2025-12-27T19:47:13","guid":{"rendered":"https:\/\/worldbodybuildingnews.com\/?p=937"},"modified":"2025-12-27T19:47:13","modified_gmt":"2025-12-27T19:47:13","slug":"retatrutide-how-people-lost-71-pounds-new-clinical-data","status":"publish","type":"post","link":"https:\/\/worldbodybuildingnews.com\/?p=937","title":{"rendered":"Retatrutide: How People Lost 71 POUNDS (New Clinical Data)"},"content":{"rendered":"<p><iframe loading=\"lazy\"  width=\"580\" height=\"385\" src=\"https:\/\/www.youtube.com\/embed\/CAGka2FY8GU\" frameborder=\"0\" allowfullscreen><\/iframe><\/p>\n<p><strong>Video Source:<\/strong> <a href=\"https:\/\/www.youtube.com\/watch?v=CAGka2FY8GU\" target=\"_blank\" rel=\"nofollow noopener\">Watch on YouTube<\/a><\/p>\n<p>Retatrutide is an investigational triple agonist (GLP-1 + GIP + glucagon) and the newest \u201cnext-gen\u201d metabolic drug everyone in the GLP-1 world is watching. In this video, Big Paul breaks down the new Phase 3 TRIUMPH-4 topline results in adults with obesity + knee osteoarthritis (without diabetes)\u2014including the absolutely wild weight-loss numbers, the arthritis pain improvement, and the side effects people keep reporting.<\/p>\n<p>What the TRIUMPH-4 topline data says (high level):<br \/>\n\u2022 Up to 28.7% average body-weight loss at 68 weeks on 12 mg (about 71.2 lbs on average).<br \/>\n\u2022 Knee pain improved by up to ~75.8%, plus better physical function.<br \/>\n\u2022 In a post-hoc analysis, ~12\u201314% of retatrutide-treated patients were completely free of knee pain at week 68 (vs ~4% placebo).<br \/>\n\u2022 Common GLP-1\u2013style side effects showed up (nausea\/diarrhea\/constipation\/vomiting), and dysesthesia (tingly\/burning skin sensation) was reported in up to 20.9% at 12 mg (vs 0.7% placebo).<br \/>\n\u2022 Trial dosing started at 2 mg once weekly, increasing every 4 weeks step-wise until the 9 mg or 12 mg target.<br \/>\n\u2022 Lilly says additional Phase 3 readouts in obesity and type 2 diabetes are expected to complete in 2026. <\/p>\n<p>We also talk about why the glucagon component may matter (energy expenditure, metabolic effects), why some people speculate these results could go beyond \u201cjust weight loss,\u201d and what to watch for as more TRIUMPH program data drops.<\/p>\n<p>\ud83d\udc47 Drop your thoughts: Is Reta the future king of fat loss meds\u2014or are the side effects the real story?<\/p>\n<p>\ud83d\udce7 For exclusive inside Information and free articles, join my mailing list: https:\/\/www.anabolicbodybuilding.com\/email-list<\/p>\n<p>Subscribe to my Clips Channel: https:\/\/www.youtube.com\/@UCjQmfhe1yyDsRjCVedA5IBA <\/p>\n<p>\ud83d\udcd8 The Science of Anabolics E-Course:<br \/>\nhttps:\/\/www.anabolicbodybuilding.com\/the-science-of-anabolics-performance-enhancing-drugs<\/p>\n<p>\ud83d\uddfa\ufe0f Get The Ultimate Cycle Cheat Sheet: https:\/\/www.anabolicbodybuilding.com\/cheatsheet<\/p>\n<p>\ud83d\udcaa Team ANABOLIC BODYBUILDING: https:\/\/www.skool.com\/teamanabolicbodybuilding<\/p>\n<p>\ud83d\udcaa For Coaching or Consultations, go to: https:\/\/www.anabolicbodybuilding.com\/<br \/>\n\ud83d\udce7 Contact BigPaul at: https:\/\/zl3h1q0lbmt.typeform.com\/to\/vqzGP4mG<\/p>\n<p>SOCIAL MEDIA<br \/>\n\ud83e\udd18 Instagram: https:\/\/www.instagram.com\/paulkbarnett\/<br \/>\n\ud83d\udd08 Spotify: https:\/\/open.spotify.com\/show\/3PKOCKSDh6ZeaLmVoHF60z<br \/>\n\ud83c\udd87 Formerly Twitter: https:\/\/twitter.com\/paulb3rd<br \/>\n\ud83e\udd2e Facebook: https:\/\/www.facebook.com\/officialanabolicbodybuilding\/<br \/>\n\ud83c\udfac RUMBLE: https:\/\/rumble.com\/c\/AnabolicBodybuilding<br \/>\n\ud83c\udf4f Apple Podcasts: https:\/\/podcasts.apple.com\/us\/podcast\/anabolic-bodybuilding\/<\/p>\n<p>\ud83d\udcd8 E-Books: https:\/\/www.anabolicbodybuilding.com\/ebooks<\/p>\n<p>\ud83d\udcaa FREE Training Programs: https:\/\/www.anabolicbodybuilding.com\/free_stuff<\/p>\n<p>\ud83e\uddea For Blood Panels: www.UltaLabTests.com\/bigpaulmedia<\/p>\n<p>\ud83d\udcd8 E-Books: https:\/\/www.anabolicbodybuilding.com\/ebooks<\/p>\n<p>\ud83d\udcaa FREE Training Programs: https:\/\/www.anabolicbodybuilding.com\/free_stuff<\/p>\n<p>#bodybuilding #retatrutide #glp1 #tirzepatide #semaglutide #weightloss #obesity #osteoarthritis #kneepain #clinicaltrials #pharma #metabolichealth #diabetes<\/p>\n<p>WARNING<br \/>\n========<br \/>\nThe Video has been made available for entertainment and educational purposes only. I do not make any warranties to the accuracy, applicability, fitness, or completeness of the content. <\/p>\n<p>The content is not intended to be a substitute for professional medical or legal advice, diagnosis, or treatment. Always seek the advice of your physician or qualified health provider. Never disregard professional medical advice or delay in seeking it because of something you have seen on this channel.<\/p>\n<p>I hereby disclaim any and all liability to any party for any direct, indirect, implied, punitive, special, incidental, or other consequential damages arising directly or indirectly from any use of the content, which is provided as is, and without warranties.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Video Source: Watch on YouTube Retatrutide is an investigational triple agonist (GLP-1 + GIP + glucagon) and the newest \u201cnext-gen\u201d metabolic drug everyone in the GLP-1 world is watching. In this video, Big Paul breaks down the new Phase 3 TRIUMPH-4 topline results in adults with obesity + knee osteoarthritis (without diabetes)\u2014including the absolutely wild [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":938,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"video","meta":{"tdm_status":"","tdm_grid_status":"","footnotes":""},"categories":[1],"tags":[],"class_list":{"0":"post-937","1":"post","2":"type-post","3":"status-publish","4":"format-video","5":"has-post-thumbnail","7":"category-news","8":"post_format-post-format-video"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Retatrutide: How People Lost 71 POUNDS (New Clinical Data) - World Bodybuilding News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/worldbodybuildingnews.com\/?p=937\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Retatrutide: How People Lost 71 POUNDS (New Clinical Data) - World Bodybuilding News\" \/>\n<meta property=\"og:description\" content=\"Video Source: Watch on YouTube Retatrutide is an investigational triple agonist (GLP-1 + GIP + glucagon) and the newest \u201cnext-gen\u201d metabolic drug everyone in the GLP-1 world is watching. In this video, Big Paul breaks down the new Phase 3 TRIUMPH-4 topline results in adults with obesity + knee osteoarthritis (without diabetes)\u2014including the absolutely wild [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/worldbodybuildingnews.com\/?p=937\" \/>\n<meta property=\"og:site_name\" content=\"World Bodybuilding News\" \/>\n<meta property=\"article:published_time\" content=\"2025-12-27T19:47:13+00:00\" \/>\n<meta name=\"author\" content=\"1wilburn\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"1wilburn\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/?p=937#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/?p=937\"},\"author\":{\"name\":\"1wilburn\",\"@id\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/#\\\/schema\\\/person\\\/3f1ebf7578fb8e614291f27a298dd3a3\"},\"headline\":\"Retatrutide: How People Lost 71 POUNDS (New Clinical Data)\",\"datePublished\":\"2025-12-27T19:47:13+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/?p=937\"},\"wordCount\":528,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/?p=937#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/wp-content\\\/uploads\\\/2025\\\/12\\\/1766864834_maxresdefault.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/worldbodybuildingnews.com\\\/?p=937#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/?p=937\",\"url\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/?p=937\",\"name\":\"Retatrutide: How People Lost 71 POUNDS (New Clinical Data) - World Bodybuilding News\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/?p=937#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/?p=937#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/wp-content\\\/uploads\\\/2025\\\/12\\\/1766864834_maxresdefault.jpg\",\"datePublished\":\"2025-12-27T19:47:13+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/#\\\/schema\\\/person\\\/3f1ebf7578fb8e614291f27a298dd3a3\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/?p=937#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/worldbodybuildingnews.com\\\/?p=937\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/?p=937#primaryimage\",\"url\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/wp-content\\\/uploads\\\/2025\\\/12\\\/1766864834_maxresdefault.jpg\",\"contentUrl\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/wp-content\\\/uploads\\\/2025\\\/12\\\/1766864834_maxresdefault.jpg\",\"width\":1280,\"height\":720},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/?p=937#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Retatrutide: How People Lost 71 POUNDS (New Clinical Data)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/#website\",\"url\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/\",\"name\":\"World Bodybuilding News\",\"description\":\"Data, Rankings, Results.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/#\\\/schema\\\/person\\\/3f1ebf7578fb8e614291f27a298dd3a3\",\"name\":\"1wilburn\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/2cc05a11852733f478dc11c33ec42f688ee60589204c9784e564d1ec3ea08bc3?s=96&d=initials&r=g&initials=Ra\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/2cc05a11852733f478dc11c33ec42f688ee60589204c9784e564d1ec3ea08bc3?s=96&d=initials&r=g&initials=Ra\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/2cc05a11852733f478dc11c33ec42f688ee60589204c9784e564d1ec3ea08bc3?s=96&d=initials&r=g&initials=Ra\",\"caption\":\"1wilburn\"},\"sameAs\":[\"https:\\\/\\\/worldbodybuildingnews.com\"],\"url\":\"https:\\\/\\\/worldbodybuildingnews.com\\\/?author=1\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Retatrutide: How People Lost 71 POUNDS (New Clinical Data) - World Bodybuilding News","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/worldbodybuildingnews.com\/?p=937","og_locale":"en_US","og_type":"article","og_title":"Retatrutide: How People Lost 71 POUNDS (New Clinical Data) - World Bodybuilding News","og_description":"Video Source: Watch on YouTube Retatrutide is an investigational triple agonist (GLP-1 + GIP + glucagon) and the newest \u201cnext-gen\u201d metabolic drug everyone in the GLP-1 world is watching. In this video, Big Paul breaks down the new Phase 3 TRIUMPH-4 topline results in adults with obesity + knee osteoarthritis (without diabetes)\u2014including the absolutely wild [&hellip;]","og_url":"https:\/\/worldbodybuildingnews.com\/?p=937","og_site_name":"World Bodybuilding News","article_published_time":"2025-12-27T19:47:13+00:00","author":"1wilburn","twitter_card":"summary_large_image","twitter_misc":{"Written by":"1wilburn","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/worldbodybuildingnews.com\/?p=937#article","isPartOf":{"@id":"https:\/\/worldbodybuildingnews.com\/?p=937"},"author":{"name":"1wilburn","@id":"https:\/\/worldbodybuildingnews.com\/#\/schema\/person\/3f1ebf7578fb8e614291f27a298dd3a3"},"headline":"Retatrutide: How People Lost 71 POUNDS (New Clinical Data)","datePublished":"2025-12-27T19:47:13+00:00","mainEntityOfPage":{"@id":"https:\/\/worldbodybuildingnews.com\/?p=937"},"wordCount":528,"commentCount":0,"image":{"@id":"https:\/\/worldbodybuildingnews.com\/?p=937#primaryimage"},"thumbnailUrl":"https:\/\/worldbodybuildingnews.com\/wp-content\/uploads\/2025\/12\/1766864834_maxresdefault.jpg","articleSection":["News"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/worldbodybuildingnews.com\/?p=937#respond"]}]},{"@type":"WebPage","@id":"https:\/\/worldbodybuildingnews.com\/?p=937","url":"https:\/\/worldbodybuildingnews.com\/?p=937","name":"Retatrutide: How People Lost 71 POUNDS (New Clinical Data) - World Bodybuilding News","isPartOf":{"@id":"https:\/\/worldbodybuildingnews.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/worldbodybuildingnews.com\/?p=937#primaryimage"},"image":{"@id":"https:\/\/worldbodybuildingnews.com\/?p=937#primaryimage"},"thumbnailUrl":"https:\/\/worldbodybuildingnews.com\/wp-content\/uploads\/2025\/12\/1766864834_maxresdefault.jpg","datePublished":"2025-12-27T19:47:13+00:00","author":{"@id":"https:\/\/worldbodybuildingnews.com\/#\/schema\/person\/3f1ebf7578fb8e614291f27a298dd3a3"},"breadcrumb":{"@id":"https:\/\/worldbodybuildingnews.com\/?p=937#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/worldbodybuildingnews.com\/?p=937"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/worldbodybuildingnews.com\/?p=937#primaryimage","url":"https:\/\/worldbodybuildingnews.com\/wp-content\/uploads\/2025\/12\/1766864834_maxresdefault.jpg","contentUrl":"https:\/\/worldbodybuildingnews.com\/wp-content\/uploads\/2025\/12\/1766864834_maxresdefault.jpg","width":1280,"height":720},{"@type":"BreadcrumbList","@id":"https:\/\/worldbodybuildingnews.com\/?p=937#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/worldbodybuildingnews.com\/"},{"@type":"ListItem","position":2,"name":"Retatrutide: How People Lost 71 POUNDS (New Clinical Data)"}]},{"@type":"WebSite","@id":"https:\/\/worldbodybuildingnews.com\/#website","url":"https:\/\/worldbodybuildingnews.com\/","name":"World Bodybuilding News","description":"Data, Rankings, Results.","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/worldbodybuildingnews.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/worldbodybuildingnews.com\/#\/schema\/person\/3f1ebf7578fb8e614291f27a298dd3a3","name":"1wilburn","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/2cc05a11852733f478dc11c33ec42f688ee60589204c9784e564d1ec3ea08bc3?s=96&d=initials&r=g&initials=Ra","url":"https:\/\/secure.gravatar.com\/avatar\/2cc05a11852733f478dc11c33ec42f688ee60589204c9784e564d1ec3ea08bc3?s=96&d=initials&r=g&initials=Ra","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/2cc05a11852733f478dc11c33ec42f688ee60589204c9784e564d1ec3ea08bc3?s=96&d=initials&r=g&initials=Ra","caption":"1wilburn"},"sameAs":["https:\/\/worldbodybuildingnews.com"],"url":"https:\/\/worldbodybuildingnews.com\/?author=1"}]}},"_links":{"self":[{"href":"https:\/\/worldbodybuildingnews.com\/index.php?rest_route=\/wp\/v2\/posts\/937","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/worldbodybuildingnews.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/worldbodybuildingnews.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/worldbodybuildingnews.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/worldbodybuildingnews.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=937"}],"version-history":[{"count":0,"href":"https:\/\/worldbodybuildingnews.com\/index.php?rest_route=\/wp\/v2\/posts\/937\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/worldbodybuildingnews.com\/index.php?rest_route=\/wp\/v2\/media\/938"}],"wp:attachment":[{"href":"https:\/\/worldbodybuildingnews.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=937"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/worldbodybuildingnews.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=937"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/worldbodybuildingnews.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=937"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}