There\u2019s a big upside to doing biohacking right. You get more energy and vitality than you know what to do with. But then what? Once diet, sleep, training, and recovery finally click into place, that mental clarity makes you ever more curious about what else is out there.<\/span><\/p>\n Every year, when I attend <\/span>Dave Asprey\u2019s biohacking conference<\/span><\/a>, I walk away with a handful of interesting ideas. Most things are the same. The familiar faces show up, people walk around sipping butter coffee wearing blue light-blocking glasses, and the usual brands have their booths. But this year, Asprey\u2019s team intentionally went beyond basic biohacking knowing that he\u2019s audience is ready for what\u2019s next. Hence, the name upgrade to \u201cBeyond Biohacking.\u201d<\/span><\/p>\n Here are five trends that stood out if you\u2019re ready to take your health optimization to another level.<\/span><\/p>\n Millions of dollars are pouring into gene therapy and cellular reprogramming on the clinical level right now. But there\u2019s a more accessible version of gene therapy built around two proteins, klotho and follistatin, that don\u2019t mess with your genome. Instead, they get your body to upregulate other proteins it\u2019s already capable of making.<\/span><\/p>\n Klotho is tied to cognitive function and cellular aging, while follistatin supports muscle growth, and researchers have been putting these to the test. A 2025 meta-analysis pooling data from eight studies and more than 6,600 subjects found a statistically significant link between <\/span>Klotho levels and better cognitive function<\/span><\/a>. Additionally, research published in<\/span> PNAS<\/span><\/i> found that a single gene-therapy injection of a follistatin variant <\/span>enhanced muscle size and strength<\/span><\/a> in animal models for more than two years.<\/span><\/p>\n Are these just another peptide? That was my first interpretation too, but they aren\u2019t. A peptide injection delivers the finished product directly, and when the body uses it up, you\u2019ll have to reinject on a regular schedule, often daily or weekly. Gene therapy skips that step. Instead of handing the body the amino acid, it hands the body the instructions for making the protein itself, turning a cell into its own small factory. That\u2019s the appeal behind a single injection lasting up to a year.<\/span><\/p>\n According <\/span>to Minicircle, <\/span><\/a>the delivery method is a plasmid, small circular DNA molecules, injected under the skin in a single dose. Though, the plasmid enters the cell\u2019s nucleus, it never merges with your own genome. The cell reads the plasmid\u2019s instructions and starts manufacturing the target protein, releasing it into the bloodstream. A single injection can support that protein production for up to a year, the company says, depending on the person.<\/span><\/p>\n Minicircle might sound unfamiliar, but if you\u2019ve seen Bryan Johnson\u2019s Netflix documentary <\/a><\/span>Don\u2019t Die: The Man Who Wants to Live Forever,<\/span><\/i> you\u2019ve already heard of it. This is the company the tech entrepreneur visits to undergo plasmid gene therapy using follistatin.<\/span><\/p>\n However, it\u2019s fair to question both efficacy and safety. Human research on these therapies is still limited, and most of what\u2019s known comes from animal studies and a small, self-selected pool of early adopters, like Asprey, rather than large clinical trials.<\/span><\/p>\n Asprey says he trusts the early results. Even his 19-year-old daughter asked to try Klotho, making her, by his account, one of the youngest people to do it.<\/span><\/p>\n \u201cThe big question is what is the potential gain and what is the potential risk,\u201d Asprey told <\/span>Muscle & Fitness<\/span><\/i>. \u201cAnd the risk seems meaningfully low because they exit the body over time. And the upside is pretty high. They are studied. There are trials. So I believe them enough that I\u2019ve done them, and so did my daughter.\u201d<\/span><\/p>\n A <\/span>Phase 1 trial<\/span><\/a> sponsored by Minicircle is currently recruiting to test this combination on humans. The trial\u2019s own listing notes that the injections are administered at a site outside the U.S., outside FDA jurisdiction, with only pre- and post-treatment assessments happening stateside.<\/span><\/p>\n Some biohackers are still walking around with over a hundred supplements in their pocket, and others have most of what their bodies need in a few pills a day. The latter group goes a layer deeper than their blood panel and supplementing based on what they may be \u201cdeficient\u201d in.\u00a0<\/span><\/p>\n A genetic test can flag the specific pathways and variants that affect how you metabolize different nutrients, process caffeine, or absorb vitamin D, so you can use your genetic code to dictate exactly what goes in your daily supplement stack. Companies in this space compound personalized formulations around those results rather than what the average person might need.<\/span><\/p>\n Dr. Bryce Wilde, genetics specialist and lead genomics coach at <\/span>Trifecta Health<\/span><\/a>, told Muscle & Fitness,<\/em> that most supplements, especially multivitamins, are formulated based on population averages. However, when it comes to demographics, like biohackers, who pay really close attention to precision, those are just not going to deliver the results they seek. \u201cYour genome is the only place where truly personalized health strategy begins,\u201d he said.<\/span><\/p>\n It\u2019s become really simple to access peptides without any clinical oversight. Since, they work, the demand is high, and there\u2019s a lot of money to be made. However, that has brought with it more shady sellers than one would like to admit.<\/span><\/p>\n Biohackers at Beyond who still swear by peptides<\/a> have gotten religious about sourcing, third-party testing, and conservative dosing. They prioritize asking the right people the right questions instead of just adding to cart and checking out on a website that makes it too easy to buy.<\/span><\/p>\n Buyer beware still applies. It always will in a market moving this fast. But when you get to connect with people with credentials and years, if not decades, of research behind them, it makes the caution a lot easier to navigate.<\/span><\/p>\n You can optimize and biohack until you\u2019re blue in the face, but there comes a point when feeling on top of the world isn\u2019t enough, especially when you\u2019re up there alone. I talked to several people who\u2019ve spent significant time and money to have the energy, clarity, and insight, but none of that would hold much weight if they\u2019re not doing something with it, sharing what they\u2019ve learned, and showing up for others the way somebody once showed up for them.<\/span><\/p>\n Jay Shetty\u2019s keynote brought exactly that to the spotlight before a room of thousands of people. Purpose, he argued, doesn\u2019t have to look like anything in particular. \u201cIt doesn\u2019t have to be a person. It doesn\u2019t have to make you famous. It doesn\u2019t have to make you money. It doesn\u2019t have to be big,\u201d he said on stage, noting it\u2019s your gift that leaves other people a little bit happier just for having crossed paths with them. <\/span><\/p>\n And many biohackers in the room are learning to discover theirs.<\/span><\/p>\n Most people will still find some of the mindfulness and consciousness tech too out there, and that reaction is fair. Even biohackers tend to arrive at this corner of their journey after their physical health has reached solid ground. Thinking, it\u2019s time to understand the deeper layers of the mind.<\/span><\/p>\n In a world constantly fighting for our attention, learning how to tune out and tune in has become a skill advanced biohackers are increasingly interested in mastering, and the technology has caught up with that demand.<\/span><\/p>\n Full-body immersive soundbath experiences pull you into your body in a way headphones never could. You\u2019re literally sitting inside a soundbath bowl, with another one suspended above your head, moving vibration through you from both directions at once.<\/span><\/p>\n Then on the higher-tech side, neurofeedback devices read your brain activity and feed that data back to you in real time in the form of sound, vibration or visual cues, so you can train to shift your brainwave patterns not just with your eyes closed, but also when they\u2019re wide open.<\/span><\/p>\n This is also just the surface of where Asprey wants to take things. He\u2019s hosting an entire event around going deeper into consciousness this fall, <\/span>Beyond Wonderland<\/span><\/a>, which suggests the mind is about to get a lot more attention at these conferences than it\u2019s gotten before.<\/span><\/p>\n<\/p><\/div>\nGene Therapy for Longevity: Why Biohackers Are Paying Attention<\/h2>\n
Klotho vs. Follistatin: What Do These Proteins Actually Do?<\/h3>\n
Personalized Supplements Based on Your DNA<\/h2>\n
![\"Lab](\"https:\/\/i0.wp.com\/www.muscleandfitness.com\/wp-content\/uploads\/2026\/06\/Lab-tech-wearing-gloves-holding-a-vile-of-peptides-.jpg?quality=86&strip=all\")
<\/div>The Hidden Risks of Buying Peptides Online<\/h2>\n
![\"Fitness](\"https:\/\/i0.wp.com\/www.muscleandfitness.com\/wp-content\/uploads\/2026\/06\/Fitness-biohacking-community-at-the-gym-.jpg?quality=86&strip=all\")
<\/div>Purpose and Community Are Becoming Essential Biohacks<\/h2>\n
![\"Female](\"https:\/\/i0.wp.com\/www.muscleandfitness.com\/wp-content\/uploads\/2026\/06\/Female-using-soundbath-to-feel-and-use-the-vibrations-for-a-healing-experience.jpg?quality=86&strip=all\")
<\/div>The Rise of Neurofeedback and Advanced Mindfulness Technology<\/h2>\n