{"id":15133,"date":"2026-02-28T11:09:37","date_gmt":"2026-02-28T11:09:37","guid":{"rendered":"https:\/\/worldbodybuildingnews.com\/?p=15133"},"modified":"2026-02-28T11:09:37","modified_gmt":"2026-02-28T11:09:37","slug":"results-before-and-after-pictures-dosages","status":"publish","type":"post","link":"https:\/\/worldbodybuildingnews.com\/?p=15133","title":{"rendered":"Results, Before and After Pictures, Dosages"},"content":{"rendered":"<p><\/p>\n<div>\n<div class=\"a-single a-9\">\n<p style=\"font-family: helvetica; font-size: 19px;\"><strong>Disclaimer<\/strong>: Only researchers are authorized to administer SARMs, as they are not FDA-approved for cosmetic use and may have adverse effects. <a href=\"https:\/\/insidebodybuilding.com\/about\/\">Dr. Touliatos<\/a> is available for consultation should readers have any questions or concerns.&#13;<br \/>\n&#13;<br \/>\n&#13;\n<\/p>\n<hr\/>\n<\/div>\n<p>RAD-140, or Testolone, is a non-steroidal selective androgen receptor modulator (SARM) that replicates the anabolic effects of anabolic steroids by binding to the androgen receptor [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2907129\/\" target=\"_blank\" rel=\"noopener\">1<\/a>].<\/p>\n<p>RAD-140 is also known as:<\/p>\n<ul>\n<li>Testalone<\/li>\n<li>EP0062<\/li>\n<li>Vosilasarm<\/li>\n<\/ul>\n<p>RAD-140 and other <a href=\"https:\/\/insidebodybuilding.com\/sarms\/\">SARMs<\/a> were formulated as a potentially efficacious and less risky treatment, compared to anabolic steroids, for patients suffering from:<\/p>\n<ul>\n<li>Osteoporosis (weak bones) [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10403398\/\" target=\"_blank\" rel=\"noopener\">2<\/a>]<\/li>\n<li>Cachexia (muscle loss) [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24189892\/\" target=\"_blank\" rel=\"noopener\">3<\/a>]<\/li>\n<li>Anemia (low red blood count)<\/li>\n<\/ul>\n<p>However, RAD-140 has not yet been proven to be safe clinically [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39755947\" target=\"_blank\" rel=\"noopener\">4<\/a>,<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10392554\/\" target=\"_blank\" rel=\"noopener\">5<\/a>,<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S266608492400216X\" target=\"_blank\" rel=\"noopener\">6<\/a>].<\/p>\n<h3>How Does RAD-140 Compare to Anabolic Steroids?<\/h3>\n<p>Although anabolic steroids produce significant increases in lean mass, they also induce negative cardiovascular, hepatic, estrogenic, and androgenic side effects in research [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10589853\/\" target=\"_blank\" rel=\"noopener\">7<\/a>,<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20020375\/\" target=\"_blank\" rel=\"noopener\">8<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548931\/\" target=\"_blank\" rel=\"noopener\">9<\/a>,<a href=\"https:\/\/ec.bioscientifica.com\/view\/journals\/ec\/9\/4\/EC-19-0557.xml\" target=\"_blank\" rel=\"noopener\">10<\/a>,<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.17567\" target=\"_blank\" rel=\"noopener\">11<\/a>]. Thus, through the mechanism of tissue selectivity, RAD-140 was synthesized to replicate the muscle-building and strength-enhancing attributes of steroids, but with limited adverse effects [<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0960076018306885\" target=\"_blank\" rel=\"noopener\">12<\/a>].<\/p>\n<p>However, in existing studies, we observe RAD-140 mimicking the toxicity of some anabolic steroids, such as Anavar or Primobolan [<a href=\"https:\/\/www.ochsnerjournal.org\/content\/22\/4\/361\" target=\"_blank\" rel=\"noopener\">13<\/a>,<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0305417918302870\" target=\"_blank\" rel=\"noopener\">14<\/a>,<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0003267004013650\" target=\"_blank\" rel=\"noopener\">15<\/a>].<\/p>\n<p>RAD-140 surfaced in 2010 after being formulated by Radius Health, a United States (US) biotechnology company. There is limited clinical research regarding RAD-140\u2019s effects, particularly on humans over the long term.<\/p>\n<h3>How Effective is RAD-140?<\/h3>\n<p>RAD-140 is considered one of the more potent SARMs, with it possessing superior anabolic effects to <a href=\"https:\/\/insidebodybuilding.com\/testosterone-propionate\/\">testosterone propionate<\/a> in animal trials.<\/p>\n<p>In one study, monkeys experienced a 10% increase in lean body mass over 28 days on RAD-140 [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/labs\/pmc\/articles\/PMC4018048\/\" target=\"_blank\" rel=\"noopener\">16<\/a>].<\/p>\n<p>Similar to anabolic steroids, RAD-140 induces lipolysis (when the body uses stored fat as a main energy source) and increases muscular strength due to its high affinity when binding to androgen receptors.<\/p>\n<p><i><strong>Disclosure:<\/strong> We do not accept any form of advertising on Inside Bodybuilding. We monetize our practice via doctor consultations and carefully chosen supplement recommendations, which have given our patients excellent results.<\/i><\/p>\n<h2>Best SARMs Company in 2026<\/h2>\n<div class=\"wpb_raw_code wpb_raw_html wpb_content_element\">\n<div class=\"wpb_wrapper\">\n<div class=\"item-box\">\n<div class=\"item-box__top\">\n<h2>Chemyo<\/h2>\n<p>    <img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-25921 alignnone\" src=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/08\/chemyo-rad-140-bottles-1.png\" alt=\"Chemyo products\" width=\"353\" height=\"243\"\/>\n <\/div>\n<div class=\"item-box__bottom\">\n<p>Chemyo is our recommended SARM source worldwide. They guarantee a minimum purity of 99% on all products.<\/p>\n<p>Chemyo offers excellent international shipping, allowing overseas researchers to access high-quality SARMs.<\/p>\n<p>US orders are delivered within 2\u20135 days, while international orders typically arrive in 4\u20137 days.<\/p>\n<p>Use discount code <b>INSIDE10<\/b> for 10% off.<\/p>\n<p><center\/>\n<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<div class=\"wpb_raw_code wpb_raw_html wpb_content_element\">\n<div class=\"wpb_wrapper\">\n<div class=\"item-box\">\n<div class=\"item-box__top\">\n<h2>Sports Technology Labs<\/h2>\n<p>    <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2022\/07\/sports-technology-labs3.png\" alt=\"Sports Technology Labs\" width=\"254\" height=\"307\"\/>\n <\/div>\n<div class=\"item-box__bottom\">\n<p>Sports Technology Labs is a highly cost-effective US SARM source, offering purity levels exceeding 98%, as confirmed by their certificates of analysis.<\/p>\n<p>Sports Technology Labs also has a no-credit-card-fee policy, whereas other sources may charge up to 10%.<\/p>\n<p>Sports Technology Labs does not currently provide shipping outside the US.<\/p>\n<p>Use discount code <b>INSIDE15<\/b> for 15% off.<\/p>\n<p><center><br \/>\n  <\/center><\/div>\n<\/div><\/div>\n<\/p><\/div>\n<h3>Is RAD-140 Legal?<\/h3>\n<p>Due to RAD-140\u2019s recent creation, it has not been approved for human use by the Food and Drug Administration (FDA). Thus, Testolone is only legal to buy for research purposes.<\/p>\n<p>RAD-140 has also been banned by the World Anti-Doping Association (WADA); therefore, professional athletes are prohibited from using it and other SARMs [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23650030\/\" target=\"_blank\" rel=\"noopener\">17<\/a>].<\/p>\n<h2><span id=\"RAD-140_Results_User_Before_and_After_Pictures\">RAD-140 Results: User Before and After Pictures<\/span><\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-14378 alignnone\" src=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after.jpg\" alt=\"RAD 140 before and after\" width=\"479\" height=\"479\" srcset=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after.jpg 1080w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after-300x300.jpg 300w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after-100x100.jpg 100w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after-600x600.jpg 600w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after-1024x1024.jpg 1024w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after-150x150.jpg 150w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after-768x768.jpg 768w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after-80x80.jpg 80w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after-500x500.jpg 500w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after-1000x1000.jpg 1000w\" sizes=\"auto, (max-width: 479px) 100vw, 479px\"\/><br \/>This Reddit user stacked RAD-140 with LGD-4033. LGD-4033 is also known as:<\/p>\n<p>He also administered MK-677, known as Ibutamoren. MK-677 is commonly referred to as a SARM due to its similar anabolic effects [<a href=\"https:\/\/academic.oup.com\/jcem\/article-abstract\/83\/2\/320\/2865101\" target=\"_blank\" rel=\"noopener\">18<\/a>]. However, MK-677 is technically a growth hormone secretagogue (GHS).<\/p>\n<p>This user experienced significant muscle growth, with some increases in visceral fat, made visible by a notable increase in stomach hypertrophy.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-14379 alignnone\" src=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after2.jpg\" alt=\"SARMs before and after transformation\" width=\"473\" height=\"473\" srcset=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after2.jpg 1080w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after2-300x300.jpg 300w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after2-100x100.jpg 100w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after2-600x600.jpg 600w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after2-1024x1024.jpg 1024w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after2-150x150.jpg 150w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after2-768x768.jpg 768w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after2-80x80.jpg 80w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after2-500x500.jpg 500w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after2-1000x1000.jpg 1000w\" sizes=\"auto, (max-width: 473px) 100vw, 473px\"\/><br \/>Increases in visceral fat may be predominantly attributed to the inclusion of MK-677 in this stack, with <a href=\"https:\/\/insidebodybuilding.com\/hgh\/\">HGH enhancers<\/a> increasing insulin resistance and lipogenesis (when sugars are converted into fat stores) in scientific literature, thus inducing visceral fat storage [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9331610\/\" target=\"_blank\" rel=\"noopener\">19<\/a>,<a href=\"https:\/\/academic.oup.com\/jcem\/article-abstract\/81\/12\/4249\/2650464\" target=\"_blank\" rel=\"noopener\">20<\/a>,<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10889795\/\" target=\"_blank\" rel=\"noopener\">21<\/a>].<\/p>\n<p>This user\u2019s results, in terms of muscle hypertrophy (size), can be considered moderate\u2014yet seemingly less than what is seen after a <a href=\"https:\/\/insidebodybuilding.com\/first-steroid-cycle\/\">first steroid cycle<\/a>.<\/p>\n<p>As a visual estimate, this user appears to have gained 10 pounds (4.5 kg) of lean mass.<\/p>\n<p>In animal trials, RAD-140 has produced significant increases in muscle hypertrophy; however, in humans, we see a milder effect.<\/p>\n<p>Human trials have compared the anabolic effects of <a href=\"https:\/\/insidebodybuilding.com\/sarms-vs-steroids\/\">testosterone enanthate versus SARMs<\/a>. Researchers found that SARMs added 1\u20131.5 kg of lean mass to participants over 4\u20136 weeks, whereas testosterone enanthate added 5\u20137 kg [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/labs\/pmc\/articles\/PMC2907129\/\" target=\"_blank\" rel=\"noopener\">1<\/a>].<\/p>\n<h2><span id=\"RAD-140-Only_Cycle_Before_and_After_Pictures\">RAD-140-Only Cycle: Before and After Pictures<\/span><\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-14382 alignnone\" src=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after3.jpeg\" alt=\"SARMs before and after results\" width=\"548\" height=\"548\" srcset=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after3.jpeg 1564w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after3-300x300.jpeg 300w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after3-100x100.jpeg 100w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after3-600x600.jpeg 600w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after3-1024x1024.jpeg 1024w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after3-150x150.jpeg 150w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after3-768x768.jpeg 768w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after3-1536x1536.jpeg 1536w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after3-80x80.jpeg 80w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after3-500x500.jpeg 500w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/sarms-before-and-after3-1000x1000.jpeg 1000w\" sizes=\"auto, (max-width: 548px) 100vw, 548px\"\/><br \/>This Reddit user\u2019s cycle:<\/p>\n<table id=\"tablepress-52\" class=\"tablepress tablepress-id-52\">\n<thead>\n<tr class=\"row-1\">\n<th class=\"column-1\">Week<\/th>\n<th class=\"column-2\">RAD-140 Dosage<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n<td class=\"column-1\">1\u201312<\/td>\n<td class=\"column-2\">17 mg\/day<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- #tablepress-52 from cache --><\/p>\n<p>He experienced modest improvements in muscularity, albeit with an increase in subcutaneous body fat.<\/p>\n<p>He gained 5 lb (2.3 kg) in weight, with some of this being in the form of adipose tissue (fat stores), due to 12 weeks of eating in a modest calorie surplus.<\/p>\n<p>In comparison to the first RAD-140 before and after transformation, this user has not gained a notable amount of visceral fat, indicating that the other user\u2019s increase in gut size was likely MK-677-related.<\/p>\n<p>Some people might speculate that the RAD-140 utilized by this user is either not legitimate or diluted, as there are no significant <a href=\"https:\/\/insidebodybuilding.com\/sarms-before-and-after-results\/\">results<\/a> observed. However, this user\u2019s source was verified to be a trusted manufacturer.<\/p>\n<h2><span id=\"RAD-140_Before_and_After_Pictures_8-Week_Cycle\">RAD-140 Before and After Pictures: 8-Week Cycle<\/span><\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-14427 alignnone\" src=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/rad-140-before-and-after.png\" alt=\"RAD-140 before and after\" width=\"492\" height=\"323\" srcset=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/rad-140-before-and-after.png 492w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2021\/09\/rad-140-before-and-after-300x197.png 300w\" sizes=\"auto, (max-width: 492px) 100vw, 492px\"\/><br \/>The above Reddit user administered less than 10 milligrams per day (mg\/day) of RAD-140 for the majority of his <a href=\"https:\/\/insidebodybuilding.com\/sarm-cycles\/\">8-week cycle<\/a>, demonstrating that notable results can still be experienced on a low dosage.<\/p>\n<p>This user experienced significant fat loss despite claiming to eat in a calorie surplus. He is displaying enhanced:<\/p>\n<ul>\n<li>Muscle hardness<\/li>\n<li>Definition<\/li>\n<li>Thickness<\/li>\n<\/ul>\n<p>Despite gaining 10 pounds on the scales, he stated that RAD-140 was not worth it for him. This was because his results were \u201cinsubstantial,\u201d and he experienced some hair loss.<\/p>\n<p>This user\u2019s experience indicates that low dosages of RAD-140 may increase its reward-to-risk ratio, with the subject gaining 10 pounds and losing a noticeable amount of subcutaneous fat simultaneously. However, individuals susceptible to male pattern baldness may experience some shedding on RAD-140. Such telogen effluvium is typically transient and does not result in long-term androgenetic alopecia (hormone-related hair loss) unless RAD-140 is abused.<\/p>\n<h2><span id=\"RAD-140_Dosage\">RAD-140 Dosage<\/span><\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-26750 alignnone\" src=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140.jpeg\" alt=\"RAD-140\" width=\"318\" height=\"311\" srcset=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140.jpeg 1206w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-300x293.jpeg 300w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-1024x999.jpeg 1024w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-768x750.jpeg 768w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-600x586.jpeg 600w\" sizes=\"auto, (max-width: 318px) 100vw, 318px\"\/><br \/>RAD-140 is not a pharmaceutically produced compound due to a lack of FDA approval. Thus, there are no dosage guidelines.<\/p>\n<p>However, we see men commonly take 10\u201320 mg\/day for 6\u201312 weeks to enhance body composition.<\/p>\n<h3>RAD-140 Cycle for Males<\/h3>\n<p>RAD-140 typically comes in 10 mg capsules or a 10 mg\/mL solution.<\/p>\n<table id=\"tablepress-53\" class=\"tablepress tablepress-id-53\">\n<thead>\n<tr class=\"row-1\">\n<th class=\"column-1\">Week<\/th>\n<th class=\"column-2\">RAD-140 Dosage<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n<td class=\"column-1\">1\u20138<\/td>\n<td class=\"column-2\">10 mg\/day<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- #tablepress-53 from cache --><\/p>\n<h3>RAD-140 Cycle for Females<\/h3>\n<p>Women may utilize 5\u201310 mg\/day for a similar duration, enabling them to experience the benefits of RAD-140 without any virilizing (masculinizing) effects.<\/p>\n<table id=\"tablepress-54\" class=\"tablepress tablepress-id-54\">\n<thead>\n<tr class=\"row-1\">\n<th class=\"column-1\">Week<\/th>\n<th class=\"column-2\">RAD-140 Dosage<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n<td class=\"column-1\">1\u20138<\/td>\n<td class=\"column-2\">7.5 mg\/day<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- #tablepress-54 from cache --><\/p>\n<h2><span id=\"What_Are_the_Side_Effects_of_RAD-140\">What Are the Side Effects of RAD-140?<\/span><\/h2>\n<p>Based on in vivo studies, the following adverse effects may occur from RAD-140 use:<\/p>\n<ul>\n<li>Liver toxicity and hepatitis [<a href=\"https:\/\/journals.lww.com\/ajg\/fulltext\/2024\/10001\/s4449_severe_drug_induced_liver_injury_due_to.4450.aspx\" target=\"_blank\" rel=\"noopener\">22<\/a>]<\/li>\n<li>Hypertension (high blood pressure) [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10420890\/\" target=\"_blank\" rel=\"noopener\">23<\/a>]<\/li>\n<li>Hypogonadism (low testosterone)<\/li>\n<li>Gynecomastia (man boobs) and edema (swelling)<\/li>\n<li>Hair loss and prostatomegaly (enlarged prostate)<\/li>\n<\/ul>\n<p>In animal studies, RAD-140 has been shown to be less toxic than testosterone replacement therapy when administered to rats.<\/p>\n<p>However, in humans, there appears to be a different trend, with RAD-140 demonstrating harsher side effects in some users. Dr. Nicholas Downey says that existing research indicates that RAD-140 causes \u201cliver issues\u201d at 50 mg\/day, increasing the risk of cholestasis, i.e., the disruption of bile flow.<\/p>\n<p>He also notes that RAD-140 is \u201cquite suppressive,\u201d but the extent of this gonadal (testicular) side effect is unknown due to a lack of human studies.<\/p>\n<h3>Liver Toxicity<\/h3>\n<p>There is existing research to suggest RAD-140 can cause hepatocellular-cholestatic liver injury [<a href=\"https:\/\/journals.lww.com\/ajg\/fulltext\/2021\/10001\/s2851_harm_by_sarm__a_case_of_drug_induced_liver.2855.aspx\" target=\"_blank\" rel=\"noopener\">24<\/a>,<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38444893\/\" target=\"_blank\" rel=\"noopener\">25<\/a>], as documented by Flores et al. (2020). A 49-year-old man had taken RAD-140 continuously for 4 weeks [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/labs\/pmc\/articles\/PMC7049679\/\" target=\"_blank\" rel=\"noopener\">26<\/a>], with intermittent use afterward. He administered RAD-140 in conjunction with venlafaxine, an antidepressant, which he had previously been taking for 11 months.<\/p>\n<p>The man\u2019s alcohol consumption was insignificant. Therefore, the combination of hepatotoxic antidepressants and SARMs may be a deleterious duo [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6061298\/\" target=\"_blank\" rel=\"noopener\">27<\/a>].<\/p>\n<p>The user in the second RAD-140 before and after picture also reported excessively raised alanine transaminase (ALT) and aspartate aminotransferase (AST) enzymes, demonstrating liver stress.<\/p>\n<p>Dr. Thomas O\u2019Connor, in his experience of analyzing over 2,000 patients utilizing SARMs over a decade, has likened their hepatotoxic (liver toxic) effects to taking 50 mg\/day of Anavar.<\/p>\n<p>Dr. Ankit Batra also affirms that in clinical studies, the hepatic complications of RAD-140 \u201ccan be similar to anabolic steroids,\u201d despite cases of hypertransaminasemia (high liver enzymes) normalizing post-cycle [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10024817\/\" target=\"_blank\" rel=\"noopener\">28<\/a>].<\/p>\n<p>RAD-140\u2019s route of entry, being an oral product, is thought to be the main cause of hepatic stress. This is due to it having to bypass the liver upon entering the bloodstream, similar to C-17 alpha-alkylated anabolic steroids, which studies have shown to be hepatotoxic [<a href=\"https:\/\/bmjopengastro.bmj.com\/content\/7\/1\/e000549\" target=\"_blank\" rel=\"noopener\">29<\/a>,<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/4423214\/\" target=\"_blank\" rel=\"noopener\">30<\/a>].<\/p>\n<p>RAD-140 users can reduce the risk of liver injury by supplementing with 500 mg\/day of tauroursodeoxycholic acid (TUDCA). TUDCA is a natural bile acid supplement that has demonstrated notable hepatoprotective effects in research and our experience.<\/p>\n<h3>Elevated Blood Pressure<\/h3>\n<p>RAD-140 and other SARMs may have a dose-dependent effect on cholesterol and triglycerides, potentially increasing the risk of:<\/p>\n<ul>\n<li>Atherosclerosis (hardening of arteries due to plaque buildup)\u00a0 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37571268\/\" target=\"_blank\" rel=\"noopener\">31<\/a>]<\/li>\n<li>Myocardial infarction (heart attack)<\/li>\n<li>Cerebrovascular accident (stroke)<\/li>\n<\/ul>\n<p>The second user, who published his before and after transformation, reported a significant rise in blood pressure.<\/p>\n<p>This is likely due to SARMs passing through the liver, which stimulates the hepatic lipase enzyme, causing high-density lipoprotein (HDL) cholesterol levels to decrease. Feig et al. (2017) found that HDL cholesterol is beneficial to heart health, with high levels reducing arterial plaque [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/labs\/pmc\/articles\/PMC5042826\/\" target=\"_blank\" rel=\"noopener\">32<\/a>].<\/p>\n<p>Another possible contributing factor to undesirable blood lipids may be RAD-140\u2019s lack of aromatization. In contrast, several anabolic steroids convert to 17\u03b2-estradiol (a type of estrogen), causing less significant shifts in cholesterol levels. This occurs due to estrogen having a positive effect on HDL levels; therefore, researchers have found that inhibiting this conversion is not optimal for cardiovascular health [<a href=\"https:\/\/academic.oup.com\/cardiovascres\/article-abstract\/69\/4\/777\/344756\" target=\"_blank\" rel=\"noopener\">33<\/a>].<\/p>\n<p>Users can combat excessive fluctuations in cholesterol and blood pressure by supplementing with vitamin K2 at 150 \u03bcg per day. We have found that vitamin K2 can lower blood pressure and prevent arterial stiffening by decreasing calcium levels in the blood.<\/p>\n<h3>Testosterone Suppression<\/h3>\n<p>RAD-140\u2019s aggressive binding effect on the androgen receptor can suppress testosterone levels and impair spermatogenesis (the production of sperm cells), similar to anabolic steroids.<\/p>\n<p>The extent of such suppression from SARMs has not yet been established. It is not uncommon for a patient\u2019s total testosterone levels to be 600 nanograms per deciliter (ng\/dL) prior to taking RAD-140, and after an 8-week cycle, for them to be approximately 300 ng\/dL.<\/p>\n<p>The second user\u2019s <em>before and after transformation<\/em> was achieved by administering 17 mg\/day of RAD-140 for 12 weeks. They experienced a notable decline in testosterone levels, dropping from 750 to 193 ng\/dL.<\/p>\n<p>Thus, clinical male hypogonadism (low testosterone) is possible with RAD-140 via damage to the hypothalamic-pituitary-testicular axis (HPTA), potentially impacting users\u2019 long-term fertility.<\/p>\n<p>All SARMs appear to have a suppressive effect on endogenous testosterone. However, RAD-140\u2019s impact appears to be more pronounced than that of other SARMs due to its potency.<\/p>\n<p>Users can utilize human chorionic gonadotropin (hCG) following a RAD-140 cycle to treat low testosterone levels. We typically prescribe a dose of 2,000 IU, administered three times per week, to aid in healing the HPTA and normalizing testosterone levels after RAD-140 supplementation.<\/p>\n<h3>Gynecomastia and Water Retention<\/h3>\n<p>Although RAD-140 does not aromatize, it can still elevate estrogen levels via a different pathway. When SARMs are administered, they begin to compete with a user\u2019s natural testosterone for binding to the androgen receptor. SARMs win this battle due to their superior binding affinity, leaving more free testosterone to convert to estrogen or dihydrotestosterone (DHT), consequently raising both of these hormones.<\/p>\n<h4>What Visual Signs May Indicate High Estrogen While Using RAD-140?<\/h4>\n<p>Elevated levels of estrogen can cause:<\/p>\n<ul>\n<li>Water retention (hydropsy)<\/li>\n<li>Bloating (meteorism)<\/li>\n<li>Gynecomastia<\/li>\n<\/ul>\n<p>Dr. Michael Moeller states that he has overseen male patients experiencing lactation from SARM use, including RAD-140. Thus, possessing a mild aromatase inhibitor (AI) when commencing a RAD-140 cycle can be advantageous [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3042921\/\" target=\"_blank\" rel=\"noopener\">34<\/a>].<\/p>\n<h4>What AIs Can Regulate Estrogen?<\/h4>\n<p>Diindolylmethane (DIM) can be utilized to inhibit estrogenic side effects, acting as a natural AI. In our experience, 200 mg\/day of DIM taken during RAD-140 cycles has been effective in regulating elevated estrogen levels.<\/p>\n<p>More potent AIs are likely to be excessively harsh for a SARM cycle, such as:<\/p>\n<ul>\n<li>Letrozole<\/li>\n<li>Exemestane<\/li>\n<li>Anastrozole<\/li>\n<\/ul>\n<p>The three above AIs may cause a hormonal imbalance, resulting in an estrogen deficiency. Potent AIs are more commonly utilized during anabolic <a href=\"https:\/\/insidebodybuilding.com\/steroid-cycles\/\">steroid cycles<\/a>, where estrogen levels rise considerably. However, these AIs remain illegal for use as post-cycle therapy (PCT) and are not prescribed by doctors for this purpose.<\/p>\n<h3>Hair Loss and Prostatomegaly<\/h3>\n<p>In animal research, it was thought that RAD-140 may benefit users with benign prostatic hyperplasia (an enlarged prostate) due to its successful tissue selectivity, causing prostate atrophy (shrinkage). In rats, RAD-140 demonstrated low levels of androgenicity. The rats required a 60-times higher dosage to replicate the prostatic hypertrophy of testosterone [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/labs\/pmc\/articles\/PMC3959610\/\" target=\"_blank\" rel=\"noopener\">35<\/a>].<\/p>\n<p>However, we have had RAD-140 users still experience androgenization (male trait development), with bouts of hair loss. This may be attributed to natural testosterone converting to DHT, with the former no longer binding to androgen receptors.<\/p>\n<p>Research indicates that higher DHT levels can increase inflammation and hair miniaturization on the scalp [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4174066\/\" target=\"_blank\" rel=\"noopener\">36<\/a>]. Saw palmetto is a natural supplement that inhibits the 5-alpha-reductase enzyme, which converts testosterone to DHT, thereby offering a remedy for this side effect. A dosage of 320 mg per day has been beneficial for our patients seeking to prevent accelerated thinning and recession during RAD-140 and other SARM cycles.<\/p>\n<h4>Can RAD-140 Accelerate Male Pattern Baldness?<\/h4>\n<p>In our experience, if users utilize RAD-140 for short-term use, small amounts of hair loss can be reversed. This occurs due to hormone regulation post-cycle. However, long-term use and sustained high levels of DHT may increase the risk of androgenetic alopecia.<\/p>\n<p>Increased sebum production is also possible, causing sensitive users to potentially experience oily skin and acne vulgaris. Supplementing with zinc can prevent bouts of acne due to it:<\/p>\n<ul>\n<li>Regulating sebum secretion<\/li>\n<li>Acting as an antibacterial agent<\/li>\n<li>Inhibiting 5-alpha-reductase<\/li>\n<\/ul>\n<p>We have found 15 mg\/day of zinc to be effective in reducing the occurrence of cystic acne during RAD-140 cycles.<\/p>\n<p>In theory, RAD-140\u2019s tissue selectivity should prevent any androgenic side effects, which are portrayed in animal research [<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1526590022001249\" target=\"_blank\" rel=\"noopener\">37<\/a>]. However, its indirect impact on natural testosterone converting to DHT may be problematic for human users.<\/p>\n<h2><span id=\"RAD-140_PCT\">RAD-140 PCT<\/span><\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-26743 alignnone\" src=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/PCT-supplement.jpeg\" alt=\"PCT supplement\" width=\"273\" height=\"276\" srcset=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/PCT-supplement.jpeg 1170w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/PCT-supplement-297x300.jpeg 297w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/PCT-supplement-1014x1024.jpeg 1014w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/PCT-supplement-768x775.jpeg 768w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/PCT-supplement-80x80.jpeg 80w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/PCT-supplement-600x606.jpeg 600w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/PCT-supplement-100x100.jpeg 100w\" sizes=\"auto, (max-width: 273px) 100vw, 273px\"\/><br \/>RAD-140 can suppress testosterone via the lowering of:<\/p>\n<ul>\n<li>Follicle-stimulating hormone (FSH)<\/li>\n<li>Luteinizing hormone (LH)<\/li>\n<\/ul>\n<p>This is a consequence of RAD-140\u2019s binding affinity to androgen receptors. Some RAD-140 users check their testosterone levels post-cycle and find out that their score has declined notably, causing them to undergo PCT.<\/p>\n<p>Users can begin PCT 12 days after finishing a RAD-140 cycle, based on its half-life of 60 hours. The elimination time is the half-life multiplied by 5.5.<\/p>\n<p>Clomid or Nolvadex can be taken during PCT, with studies showing Nolvadex to be the stronger medication for restoring endogenous testosterone [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19359408\/\" target=\"_blank\" rel=\"noopener\">38<\/a>,<a href=\"https:\/\/academic.oup.com\/jcem\/article-abstract\/95\/12\/5443\/2835341\" target=\"_blank\" rel=\"noopener\">39<\/a>].<\/p>\n<p>In our experience, Clomid is sufficient for post-cycle therapy if conducting a RAD-140-only cycle. However, we find that Nolvadex is more optimal for users stacking RAD-140 with other SARMs.<\/p>\n<p>Clomid increases testosterone due to its agonistic effects on estrogen receptors in the hypothalamus (brain control center), causing an increase in gonadotropin secretion via the anterior pituitary gland. In simple terms, Clomid helps increase testosterone by tricking the brain into thinking there is less estrogen. When this happens, the brain sends stronger signals to the testes to enhance testosterone production.<\/p>\n<p>Nolvadex also increases testosterone biosynthesis by stimulating the release of gonadotropins (reproductive hormones) from the pituitary gland.<\/p>\n<p>In terms of the dosage and duration of a RAD-140 PCT protocol, below are a couple of sample cycles.<\/p>\n<table id=\"tablepress-57\" class=\"tablepress tablepress-id-57\">\n<thead>\n<tr class=\"row-1\">\n<th class=\"column-1\">Duration <\/th>\n<th class=\"column-2\">Nolvadex Dosage<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n<td class=\"column-1\">Day 1\u201330<\/td>\n<td class=\"column-2\">20 mg\/day<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- #tablepress-57 from cache --><\/p>\n<table id=\"tablepress-58\" class=\"tablepress tablepress-id-58\">\n<thead>\n<tr class=\"row-1\">\n<th class=\"column-1\">Duration <\/th>\n<th class=\"column-2\">Clomid Dosage <\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n<td class=\"column-1\">Day 1\u201330<\/td>\n<td class=\"column-2\">25 mg\/day<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- #tablepress-58 from cache --><\/p>\n<div class=\"wpb_raw_code wpb_raw_html wpb_content_element\">\n<div class=\"wpb_wrapper\">\n<div class=\"item-box\">\n<div class=\"item-box__top\">\n<h2><span id=\"Legal_RAD-140_Alternative\">Legal RAD-140 Alternative<\/span><\/h2>\n<p>    <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2026\/02\/RAD-140-alternative.jpeg\" height=\"301\" width=\"300\" alt=\"RAD-140 alternative\"\/>\n  <\/div>\n<div class=\"item-box__bottom\">\n<p>TESTOL 140 is our recommended RAD-140 alternative, mimicking the anabolic effects of RAD-140 but without any testosterone suppression or liver toxicity.<\/p>\n<p><em>It is FDA-approved and thus legal to purchase for human consumption.<\/em><\/p>\n<p>TESTOL 140 is best utilized when bulking for maximum hypertrophy and strength. It can also inhibit fat gain when eating in a calorie surplus.<\/p>\n<p><center><center><br \/>\n  <\/center><\/center><\/div>\n<\/div><\/div>\n<\/p><\/div>\n<h2><span id=\"What_is_the_Half-Life_of_RAD-140\">What is the Half-Life of RAD-140?<\/span><\/h2>\n<p>Based on pharmacokinetic samples, RAD-140\u2019s half-life is 60 hours [<a href=\"https:\/\/cancerres.aacrjournals.org\/content\/80\/4_Supplement\/P5-11-01\" target=\"_blank\" rel=\"noopener\">40<\/a>]. However, daily dosing remains a common protocol among users, who initially estimated its half-life to be approximately 20 hours.<\/p>\n<h2><span id=\"RAD-140_vs_LGD-4033_What_is_the_Difference\">RAD-140 vs. LGD-4033: What is the Difference?<\/span><\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-26747 alignnone\" src=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/LGD-4033.jpeg\" alt=\"LGD-4033\" width=\"242\" height=\"235\" srcset=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/LGD-4033.jpeg 1206w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/LGD-4033-300x292.jpeg 300w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/LGD-4033-1024x997.jpeg 1024w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/LGD-4033-768x748.jpeg 768w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/LGD-4033-600x584.jpeg 600w\" sizes=\"auto, (max-width: 242px) 100vw, 242px\"\/><br \/>LGD-4033, or Ligandrol, is the more potent SARM per milligram compared to RAD-140. We have found that dosages of only 2\u201310 mg are necessary to see notable <a href=\"https:\/\/insidebodybuilding.com\/lgd-4033-ligandrol\/\">results from LGD-4033<\/a>. RAD-140\u2019s dosage is typically 10\u201320 mg.<\/p>\n<p>RAD-140 appears to be the superior SARM in regard to increased:<\/p>\n<ul>\n<li>Pumps<\/li>\n<li>Subcutaneous fat loss<\/li>\n<\/ul>\n<p>Thus, in terms of aesthetics, RAD-140 may be considered more optimal. We find that LGD-4033 causes more water retention; therefore, it may not be advantageous for users seeking:<\/p>\n<ul>\n<li>A lean physique<\/li>\n<li>Maximum muscle definition<\/li>\n<\/ul>\n<p>A portion of the fat loss associated with RAD-140 may be indirect, due to it increasing satiation (the feeling of fullness that ends hunger). 27% of metastatic breast cancer patients also reported decreased appetite during the first-in-human, phase 1 study of RAD-140. In our experience, its appetite suppressant effects are superior to LGD-4033\u2019s [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34565686\/\" target=\"_blank\" rel=\"noopener\">41<\/a>].<\/p>\n<p>In terms of muscle hypertrophy (size) and strength, LGD-4033 and RAD-140 are similar in potency. RAD-140 has a stronger muscle-hardening effect, possibly due to estrogen levels rising less and thus decreasing water retention. Researchers found that RAD-140 suppresses the estrogen receptor 1 (ESR1) gene [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28974548\/\" target=\"_blank\" rel=\"noopener\">42<\/a>], which is believed to be the mechanism behind it causing less extracellular water volume (fluid outside of the cells).<\/p>\n<p>RAD-140 is likely to produce more prominent results in terms of muscular endurance, benefiting those who perform high numbers of repetitions or have a training schedule that incorporates regular cardiovascular training.<\/p>\n<p>We typically find that subjects report higher energy levels on RAD-140 than on LGD-4033.<\/p>\n<p>LGD-4033, however, is known to increase libido more than RAD-140 on-cycle, according to our patients\u2019 feedback.<\/p>\n<h2><span id=\"What_is_the_Price_of_RAD-140\">What is the Price of RAD-140?<\/span><\/h2>\n<table id=\"tablepress-56\" class=\"tablepress tablepress-id-56\">\n<thead>\n<tr class=\"row-1\">\n<th class=\"column-1\">RAD-140 Price<\/th>\n<th class=\"column-2\">LGD-4033 Price<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n<td class=\"column-1\">$64.99<\/td>\n<td class=\"column-2\">$59.99<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- #tablepress-56 from cache --><\/p>\n<p>Price source: Sports Technology Labs.<\/p>\n<h2><span id=\"What_Are_RAD-1408217s_Stacking_Options\">What Are RAD-140\u2019s Stacking Options?<\/span><\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-26749 alignnone\" src=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-stack.jpeg\" alt=\"RAD-140 stack\" width=\"303\" height=\"259\" srcset=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-stack.jpeg 1196w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-stack-300x257.jpeg 300w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-stack-1024x876.jpeg 1024w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-stack-768x657.jpeg 768w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-stack-600x513.jpeg 600w\" sizes=\"auto, (max-width: 303px) 100vw, 303px\"\/><br \/>RAD-140 can theoretically be cycled with any SARM. Such stacking enhances:<\/p>\n<ul>\n<li>Muscular strength<\/li>\n<li>Hypertrophy<\/li>\n<li>Fat loss<\/li>\n<\/ul>\n<p>However, according to Leciejewska et al. (2023), utilizing multiple SARMs simultaneously can also exacerbate side effects [<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0303720723001880#bib27\" target=\"_blank\" rel=\"noopener\">43<\/a>].<\/p>\n<p>We have observed novices complete a RAD-140-only cycle initially to become accustomed to the drug. As a user gains experience, a more potent stack is commonly utilized, such as RAD-140 and LGD-4033, for additional mass and strength results when bulking [<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4111291\/\" target=\"_blank\" rel=\"noopener\">44<\/a>].<\/p>\n<p>In terms of dosages, a RAD-140 and LGD-4033 stack can look as follows:<\/p>\n<table id=\"tablepress-55\" class=\"tablepress tablepress-id-55\">\n<thead>\n<tr class=\"row-1\">\n<th class=\"column-1\">Week <\/th>\n<th class=\"column-2\">RAD-140 Dosage<\/th>\n<th class=\"column-3\">LGD-4033 Dosage<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n<td class=\"column-1\">1\u20138<\/td>\n<td class=\"column-2\">10 mg\/day<\/td>\n<td class=\"column-3\">6 mg\/day<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- #tablepress-55 from cache --><\/p>\n<p>However, given the early indications of RAD-140\u2019s hepatotoxic effects in human research [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7535764\/\" target=\"_blank\" rel=\"noopener\">45<\/a>] and its negative effects on blood lipids (fats in the bloodstream), it may not be wise to stack it with additional non-steroidal SARMs until it is more thoroughly understood.<\/p>\n<h2><span id=\"RAD-140_Reviews_How_Are_Subjects_Responding\">RAD-140 Reviews: How Are Subjects Responding?<\/span><\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-26751 alignnone\" src=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-supplement.jpeg\" alt=\"RAD-140 supplement\" width=\"253\" height=\"248\" srcset=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-supplement.jpeg 1206w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-supplement-300x295.jpeg 300w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-supplement-1024x1006.jpeg 1024w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-supplement-768x755.jpeg 768w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-supplement-600x590.jpeg 600w\" sizes=\"auto, (max-width: 253px) 100vw, 253px\"\/><br \/>Researchers in our private Facebook group have shared their RAD-140 reviews and experiences below.<\/p>\n<blockquote>\n<p>RAD-140 is far stronger than LGD-4033, a great performance-enhancing SARM.<\/p>\n<\/blockquote>\n<hr\/>\n<blockquote>\n<p>RAD-140 gives me too many side effects when I cycle it. If you utilize RAD-140, you might as well run anabolic-androgenic steroids (AAS), I think.<\/p>\n<\/blockquote>\n<hr\/>\n<blockquote>\n<p>RAD-140 is incredible. I just hit the 1,000-pound club at 52 years old with a body weight of 158 pounds.<\/p>\n<\/blockquote>\n<hr\/>\n<blockquote>\n<p>I ran my first 12-week cycle of RAD-140 six months ago with no side effects or testosterone suppression that I could notice.<\/p>\n<\/blockquote>\n<hr\/>\n<blockquote>\n<p>First day of week six on RAD-140, zero side effects, and everything is going great. 12.5 mg per day is all I need to stay lean while adding muscle and strength on all my lifts. I increased my calories by roughly 300 a day over the past two weeks to maximize my protein intake. My arms are extremely vascular. I love it!<\/p>\n<\/blockquote>\n<hr\/>\n<blockquote>\n<p>RAD-140 is my favorite SARM. But for some reason, I always get night sweats towards the end of a cycle. Right now it is pretty bad; I will be lucky to get 5\u20136 hours of sleep a night because I wake up completely drenched. And that is not normal for me. Also, I do not know for a fact that RAD-140 is causing this effect, but it is something I have observed.<\/p>\n<\/blockquote>\n<hr\/>\n<h2><span id=\"Frequently_Asked_Questions\">Frequently Asked Questions<\/span><\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-23098 alignnone\" src=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-FAQs.jpg\" alt=\"RAD-140 FAQs\" width=\"165\" height=\"191\" srcset=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-FAQs.jpg 262w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-FAQs-259x300.jpg 259w\" sizes=\"auto, (max-width: 165px) 100vw, 165px\"\/><\/p>\n<h3>Are There Specific Health Conditions That Would Contraindicate the Use of RAD-140?<\/h3>\n<p>The health of hypertensive (high blood pressure) individuals can deteriorate as a result of RAD-140 use, attributed to changes in cholesterol. One patient was suffering from high blood pressure prior to their appointment. After stacking RAD-140 with LGD-4033 for an eight-week cycle, they were diagnosed with atherosclerosis (when plaque builds up inside the arteries).<\/p>\n<p>Another patient developed peliosis hepatis (when blood-filled cavities or holes develop in the liver) after supplementing with 20 mg of RAD-140 per day for 12 weeks, in conjunction with monoamine oxidase inhibitors.<\/p>\n<h3>Can Users Drink Alcohol on RAD-140?<\/h3>\n<p>RAD-140 can exhibit hepatotoxic effects. Therefore, combining RAD-140 with alcohol during a cycle may increase the risk of hepatic (liver) injury.<\/p>\n<h3>What is the Optimal Diet When Supplementing With RAD-140?<\/h3>\n<p>In our experience, users commonly administer RAD-140 for bulking purposes. Thus, based on this objective, consuming 500 calories over maintenance can enhance anabolism [<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0261561424003467\" target=\"_blank\" rel=\"noopener\">46<\/a>].<\/p>\n<p>If RAD-140 is utilized for cutting purposes, we have found a calorie deficit of 500 to be efficacious in enhancing fat loss while maintaining muscle hypertrophy [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18549992\/\" target=\"_blank\" rel=\"noopener\">47<\/a>].<\/p>\n<h3>Are There Any Supplements That Can Help Reduce Toxicity Associated With RAD-140?<\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-26752 alignnone\" src=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/TUDCA.jpeg\" alt=\"TUDCA\" width=\"251\" height=\"311\" srcset=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/TUDCA.jpeg 1034w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/TUDCA-242x300.jpeg 242w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/TUDCA-827x1024.jpeg 827w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/TUDCA-768x951.jpeg 768w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/TUDCA-600x743.jpeg 600w\" sizes=\"auto, (max-width: 251px) 100vw, 251px\"\/><br \/>Yes, TUDCA is advantageous in reducing AST and ALT levels [<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0011393X05806599\" target=\"_blank\" rel=\"noopener\">48<\/a>], which may be beneficial during a RAD-140 cycle.<\/p>\n<p>Furthermore, users can supplement with 3 grams\/day of fish oil, containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), in an attempt to control blood pressure.<\/p>\n<p>Clinical research also reflects this reduced cardiovascular risk from fish oil, although the results vary depending on the dose [<a href=\"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.121.025071\" target=\"_blank\" rel=\"noopener\">49<\/a>].<\/p>\n<h3>Can RAD-140 Cause Bloating?<\/h3>\n<p>Some of our patients can experience bloating from RAD-140. Lowering sodium intake has been successful in alleviating this adverse effect due to decreased plasma osmolality (concentration of particles in the blood).<\/p>\n<p>After modifying their diet in this manner to encourage diuresis (increased urination), our patients have lost up to six pounds of water weight during RAD-140 cycles.<\/p>\n<h2><span id=\"RAD-140_Pros_and_Cons\">RAD-140 Pros and Cons<\/span><\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-26748 alignnone\" src=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-bottle.jpeg\" alt=\"RAD-140 bottle\" width=\"281\" height=\"278\" srcset=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-bottle.jpeg 1206w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-bottle-300x297.jpeg 300w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-bottle-1024x1014.jpeg 1024w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-bottle-768x760.jpeg 768w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-bottle-80x80.jpeg 80w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-bottle-600x594.jpeg 600w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/RAD-140-bottle-100x100.jpeg 100w\" sizes=\"auto, (max-width: 281px) 100vw, 281px\"\/><br \/><strong>Pros:<\/strong><\/p>\n<ul>\n<li>Enhanced muscle hypertrophy<\/li>\n<li>Significant increase in muscular strength<\/li>\n<li>Fat loss<\/li>\n<\/ul>\n<p><strong>Cons:<\/strong><\/p>\n<ul>\n<li>Smaller increases in fat-free mass compared to anabolic steroids<\/li>\n<li>May increase cholesterol<\/li>\n<li>Decreases endogenous testosterone<\/li>\n<li>Hepatotoxic effects<\/li>\n<\/ul>\n<h2><span id=\"Summary\">Summary<\/span><\/h2>\n<p>RAD-140 displays anabolic traits that may be beneficial to those seeking improvements in:<\/p>\n<ul>\n<li>Muscle hypertrophy<\/li>\n<li>Strength<\/li>\n<\/ul>\n<p>However, there appear to be anabolic steroid-like risks associated with RAD-140, particularly concerning liver toxicity and cardiovascular strain.<\/p>\n<p>Such deteriorations in health are evident in several human trials and correlate with Dr. Thomas O\u2019Connor\u2019s ten years of experience treating males and females on RAD-140.<\/p>\n<p>With cardiotoxic and hepatotoxic effects occurring in some users, combined with modest results regarding muscular hypertrophy, RAD-140 may be less optimal than some anabolic steroids, such as:<\/p>\n<p>Testosterone is also known as:<\/p>\n<ul>\n<li>Depo-Testosterone<\/li>\n<li>Testoviron<\/li>\n<li>AndroGel<\/li>\n<li>TestoGel<\/li>\n<li>Andriol<\/li>\n<li>Aveed<\/li>\n<\/ul>\n<p>Anavar is also known as:<\/p>\n<ul>\n<li>Oxandrin<\/li>\n<li>Lonovar<\/li>\n<li>Protivar<\/li>\n<li>Vasorome<\/li>\n<\/ul>\n<p>Deca-Durabolin is known as:<\/p>\n<ul>\n<li>19-Nortestosterone 17\u03b2-decanoate<\/li>\n<li>Rolon<\/li>\n<\/ul>\n<h3>What is Dr. O\u2019Connor\u2019s Experience With RAD-140?<\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-23099 alignnone\" src=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/Dr.-OConnor.jpg\" alt=\"Dr. Thomas O'Connor\" width=\"313\" height=\"227\" srcset=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/Dr.-OConnor.jpg 1066w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/Dr.-OConnor-600x435.jpg 600w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/Dr.-OConnor-300x218.jpg 300w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/Dr.-OConnor-1024x743.jpg 1024w, https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2025\/01\/Dr.-OConnor-768x557.jpg 768w\" sizes=\"auto, (max-width: 313px) 100vw, 313px\"\/><br \/>Dr. O\u2019Connor believes SARMs, such as RAD-140, are \u201cpotentially more dangerous than anabolic steroids,\u201d following regular analysis of over 2,000 patients\u2019 laboratory tests. Nevertheless, further clinical research on RAD-140 is required to fully understand its effects, with certain researchers observing positive changes in body composition without any discernible complications.<\/p>\n<h2 class=\"sabox-guest-authors\">Co Authors :<\/h2>\n<div class=\"sabox-guest-authors-container\">\n<div class=\"saboxplugin-wrap\" itemtype=\"http:\/\/schema.org\/Person\" itemscope=\"\" itemprop=\"author\">\n<div class=\"saboxplugin-tab saboxplugin-tab-about\">\n<div class=\"saboxplugin-gravatar\"><a href=\"https:\/\/insidebodybuilding.com\/author\/tom\/\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/insidebodybuilding.com\/wp-content\/uploads\/2022\/03\/doc2.jpg\" width=\"100\" height=\"100\" alt=\"doctor o'connor\" itemprop=\"image\"\/><\/a><\/div>\n<div class=\"saboxplugin-desc\">\n<div itemprop=\"description\">\n<p align=\"left\" style=\"font-size: 14px !important\"><a href=\"https:\/\/healow.com\/apps\/provider\/thomas-oconnor-3201094\" target=\"_blank\" rel=\"noopener\" style=\"font-size: 14px !important\">Dr. O\u2019Connor<\/a> has over 20 years of experience treating men and women with a history of anabolic steroid, SARM, and PED use. He has been a board-certified MD since 2005 and provides guidance on harm reduction methodologies.<\/p>\n<p align=\"left\" style=\"font-size: 14px !important\">Dr. O\u2019Connor is a clinical instructor at the <a href=\"https:\/\/medicine.uconn.edu\/\" target=\"_blank\" rel=\"noopener\" style=\"font-size: 14px !important\">University of Connecticut School of Medicine<\/a> and has been featured in various media publications, including <a href=\"https:\/\/generationiron.com\/tag\/dr-thomas-oconnor\/\" target=\"_blank\" rel=\"noopener\" style=\"font-size: 14px !important\">Generation Iron<\/a>, <a href=\"https:\/\/www.youtube.com\/watch?v=zXjkXMH6grs&amp;ab_channel=Dr.PhilPrimetime\" target=\"_blank\" rel=\"noopener\" style=\"font-size: 14px !important\">Dr. Phil<\/a>, <a href=\"https:\/\/www.youtube.com\/watch?v=_ripvSoRb0Y&amp;ab_channel=NationalGeographic\" target=\"_blank\" rel=\"noopener\" style=\"font-size: 14px !important\">National Geographic<\/a>, <a href=\"https:\/\/www.nytimes.com\/2018\/04\/12\/well\/move\/sarms-muscle-body-building-weight-lifting-pill-supplements-safety.html\" target=\"_blank\" rel=\"noopener\" style=\"font-size: 14px !important\">The New York Times<\/a>, <a href=\"https:\/\/www.muscleandfitness.com\/athletes-celebrities\/news\/how-much-pro-bodybuilders-success-dependent-steroids\/\" target=\"_blank\" rel=\"noopener\" style=\"font-size: 14px !important\">Muscle and Fitness<\/a>, and others.<\/p>\n<p align=\"left\" style=\"font-size: 14px !important\">Dr. O\u2019Connor also co-authored the largest survey on anabolic steroid use, involving 2,385 men, published in the peer-reviewed <a href=\"https:\/\/journals.sagepub.com\/doi\/full\/10.1177\/1557988320966536\" target=\"_blank\" rel=\"noopener\" style=\"font-size: 14px !important\">American Journal of Men\u2019s Health<\/a>.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p>You do not have any posts.<\/p>\n<\/div>\n<\/div>\n<div id=\"sp_easy_accordion-1730299441\">\n<div id=\"sp-ea-20884\" class=\"sp-ea-one sp-easy-accordion\" data-ea-active=\"ea-click\" data-ea-mode=\"vertical\" data-preloader=\"\" data-scroll-active-item=\"\" data-offset-to-scroll=\"0\">\n<div class=\"ea-card sp-ea-single\">\n<div class=\"sp-collapse spcollapse spcollapse\" id=\"collapse208840\" data-parent=\"#sp-ea-20884\" role=\"region\" aria-labelledby=\"ea-header-208840\">\n<div class=\"ea-body\">\n<ul>\n<li>According to Brown et al. (2023), RAD-140 may be an effective treatment for individuals suffering from sarcopenia (muscle loss). However, RAD-140 does not induce muscle hypertrophy at elevated dosages of 5 mg\/kg (<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1440-1681.13824\" target=\"_blank\" rel=\"noopener\">50<\/a>).<\/li>\n<li>Researchers concluded that RAD-140 demonstrated &#8220;acceptable safety&#8221; in its first human trial (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34565686\/\" target=\"_blank\" rel=\"noopener\">51<\/a>).<\/li>\n<li>In a clinical vignette, a 31-year-old male was diagnosed with scleral icterus (yellowing of the eyes) and jaundice after 12 weeks of RAD-140 supplementation (<a href=\"https:\/\/journals.lww.com\/ajg\/fulltext\/2020\/10001\/s2718_harmful_gains__drug_induced_liver_injury.2717.aspx\" target=\"_blank\" rel=\"noopener\">52<\/a>).<\/li>\n<li>During a 2020 case study, an individual developed jaundice and pruritus (itching) following a 7-week cycle of RAD-140 and LGD-4033 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33062783\/\" target=\"_blank\" rel=\"noopener\">53<\/a>).<\/li>\n<li>Flores et al. (2020) documented a 49-year-old with moderate cholestasis (blocked bile flow) after a 4-week cycle of RAD-140 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32140660\/\" target=\"_blank\" rel=\"noopener\">54<\/a>).<\/li>\n<li>In a 2022 case report, a 23-year-old experienced jaundice following a 12-week cycle of RAD-140, LGD-4033, and YK-11\u00a0(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35253885\/\" target=\"_blank\" rel=\"noopener\">55<\/a>).<\/li>\n<li>A 43-year-old male was reported to have scleral icterus (yellowing of the whites of the eyes) and hyperbilirubinemia (high bilirubin levels) after an 8-week RAD-140-only cycle (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10911832\/\" target=\"_blank\" rel=\"noopener\">56<\/a>).<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><a href=\"https:\/\/insidebodybuilding.com\/rad-140-testolone\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Disclaimer: Only researchers are authorized to administer SARMs, as they are not FDA-approved for cosmetic use and may have adverse effects. Dr. Touliatos is available for consultation should readers have any questions or concerns.&#13; &#13; &#13; RAD-140, or Testolone, is a non-steroidal selective androgen receptor modulator (SARM) that replicates the anabolic effects of anabolic steroids [&hellip;]<\/p>\n","protected":false},"author":516,"featured_media":15134,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"tdm_status":"","tdm_grid_status":"","footnotes":""},"categories":[1],"tags":[],"class_list":{"0":"post-15133","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-news"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Results, Before and After Pictures, Dosages - World Bodybuilding News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/worldbodybuildingnews.com\/?p=15133\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Results, Before and After Pictures, Dosages - World Bodybuilding News\" \/>\n<meta property=\"og:description\" content=\"Disclaimer: Only researchers are authorized to administer SARMs, as they are not FDA-approved for cosmetic use and may have adverse effects. 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